Alzheimer's with Agitation
Pediatric Migraine

Alzheimer's With Agitation

Alzheimer’s disease is typically associated with memory loss, but in more than half of people, it can also cause agitation. When a person develops agitation, his or her behaviour can change in ways that seem out of character or extreme. Agitated behaviours can be nonaggressive or aggressive. Agitation may also be a sign that a person’s Alzheimer’s disease is getting worse.

TO PARTICIPATE IN THIS STUDY, VOLUNTEERS MUST: 

  • Be 50 to 90 years old

  • Have moderate to severe agitation associated with Alzheimer's dementia

  • Have a carer who can attend all study visits

Mild to Moderate Alzheimer's Disease

Be a part of a unique opportunity to help advance Alzheimer's research and be a part of the change for future generations.

TO PARTICIPATE IN THIS STUDY, VOLUNTEERS MUST: 

  • People who are from 60 to 85 years of age at the beginning of their study participation

  • Show medical evidence of mild to moderate Alzheimer’s Disease.

  • Generally healthy enough to participate in all study activities and travel

  • Have shown an important decline in memory and daily function from a previous level of ability

  • Cause of memory loss is not due to stroke, cardiovascular, or other non-Alzheimer’s causes

  • No episodes of violence or aggression

  • Not taking insulin

  • Has never been diagnosed with breast cancer

Mild to Moderate Alzheimer's Disease

Moderate to Severe Atopic Dermatitis

Atopic dermatitis (AD) is a chronic skin condition characterized by patches of dry, inflamed, and itchy skin. The exact cause of AD isn’t well understood. One factor may be an overproduction of cells in your immune system that promote inflammation.

AD often starts in childhood and tends to flare up periodically. During flare-ups, people with AD often scratch the affected area. This scratching can lead to more skin inflammation and make symptoms worse.

TO PARTICIPATE IN THIS STUDY, VOLUNTEERS MUST: 

  • People who are from 18 to 75 years of age at the beginning of their study participation

  • Show medical evidence of moderate to severe Atopic Dermatitis

  • Has at least a 12 month history of AD, with no significant flares in the past 4 weeks

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Pediatric Migraine

Migraine is a moderate-to-severe headache that lasts from 2 to 48 hours and usually occurs two to four times per month. Migraine, also called an acute recurrent headache, occurs in about 3% of children of preschool children, 4% to 11% of elementary school-aged children, and 8% to 15% of high school-aged children. In early childhood and before puberty, migraine is more commonly seen in boys than girls. In adolescence, migraine affects young women more than young men. As adults, women are three times more likely to have a migraine than men.

TO PARTICIPATE IN THIS STUDY, VOLUNTEERS MUST: 

  • Male and Female participants ≥ 6 to < 18 years of age.

  • Must have a weight ≥ 15 kg (33lb)

  • History of migraine for ≥ 6 months prior to screening

  • History of 1 to 8 moderate or severe migraine attacks per month